Last of all, clonidine boosts neuraxial opioids and, together with fentanyl, interacts in an additive way, which might lessen the dose of each element by 60% for postoperative analgesia.Jun ten, 2024 · If clonidine therapy is to be replaced by a ?-blocker, hold off administration with the ?-blocker for quite a few days soon after clonidine therap